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KMID : 1123920140280060636
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 6 p.636 ~ p.642
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Effects of Angelicae Dahuricae Radix on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis in mice
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Jung Young-Chul
Yun Chan-Yong
Ryu Jeong-Hyun
Jo Su-Zy
Cheon Won-Ju
Kim Hyung-Woo
Cho Su-In
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Abstract
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In the theory of Korean medicine, Angelicae Dahuricae Radix (ADR) can expel wind and relieve exterior syndrome, and eliminate dampness. Recently, ADR has been reported to have possibilities as anti-inflammatory agent and cosmetics. The purpose of this study is to evaluate the efficacy of ADR on contact dermatitis (CD). In order to investigate the anti-inflammatory effects of ADR on CD, we investigated the effects of ADR on ear thickness, ear weight, skin lesion and histopathological changes in mice with CD induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). In addition, the effect on spleen weight was also measured. In our results, topical application of ADR lowered ear thickness and weight respectively. ADR treatment also improved skin lesions such as erythema and scale. In the histopathological observation, ADR-treated group showed diminished epidermal hyperplasia and immune cell infiltration in inflammed tissues compared to those of non-treated control group. In conclusion, These data suggest that ADR has anti-inflammatory action in inflammed skin tissue, resulting in improving skin lesion and histopathological abnormalities of CD.
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KEYWORD
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Angelicae Dahuricae Radix, Contact dermatitis, herbal medicine, eczema
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